You completed most of the game and suddenly there is a question in mind. What’s the Most Powerful Handgun in Resident Evil 4 Remake? Honestly, there are many candidates in the game for that, but we have to shortlist and give you the best one so far. Read the guide for that!

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Highest Damage Handgun
When it comes to the highest damage for a handgun in Resident Evil 4 Remake, there is not even a single competitor near the Red 9. It is absolutely a beast.
Best Overall Handgun
Red 9 might be the king of damage, but when it comes to versatility, usability, and other aspects, Blacktail is the real beast. It also takes around 4 slots instead of 6.
Conclusion
When you ask What’s the Most Powerful Handgun in Resident Evil 4 Remake to any gamer out there, the answer is going to be Red 9 and Blacktail. Both are exceptional to use in the game, so it’s basically your choice in the end.
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